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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1813 1
1830 2
1836 2
1839 1
1842 1
1847 1
1848 1
1861 1
1864 1
1867 1
1874 2
1875 1
1879 2
1880 2
1882 1
1883 4
1887 2
1888 1
1890 1
1891 1
1892 1
1894 1
1895 1
1897 4
1898 1
1899 2
1900 1
1901 2
1902 5
1903 2
1904 2
1905 7
1906 3
1907 2
1908 7
1909 7
1910 4
1911 7
1912 8
1913 17
1914 10
1915 10
1916 11
1917 9
1918 13
1919 5
1920 22
1921 20
1922 20
1923 19
1924 12
1925 17
1926 15
1927 20
1928 18
1929 13
1930 22
1931 19
1932 25
1933 18
1934 20
1935 16
1936 16
1937 18
1938 17
1939 24
1940 17
1941 18
1942 9
1943 11
1944 13
1945 32
1946 96
1947 99
1948 103
1949 109
1950 111
1951 140
1952 175
1953 197
1954 181
1955 215
1956 233
1957 220
1958 245
1959 257
1960 289
1961 248
1962 327
1963 405
1964 416
1965 440
1966 484
1967 545
1968 571
1969 721
1970 755
1971 792
1972 833
1973 855
1974 919
1975 3149
1976 3421
1977 3193
1978 3432
1979 3727
1980 4109
1981 4464
1982 4943
1983 6061
1984 6721
1985 7064
1986 7505
1987 8065
1988 8647
1989 10686
1990 10985
1991 11904
1992 12789
1993 13827
1994 14132
1995 15235
1996 16012
1997 16941
1998 17701
1999 18745
2000 20257
2001 21208
2002 22402
2003 24104
2004 26689
2005 29751
2006 32538
2007 35247
2008 37707
2009 40040
2010 44190
2011 47997
2012 52147
2013 55952
2014 58322
2015 60724
2016 61333
2017 63427
2018 66344
2019 69828
2020 81526
2021 88576
2022 88223
2023 88570
2024 39321

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1,361,394 results

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Toll-like receptor signaling.
Lim KH, Staudt LM. Lim KH, et al. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a011247. doi: 10.1101/cshperspect.a011247. Cold Spring Harb Perspect Biol. 2013. PMID: 23284045 Free PMC article. Review.
Toll-like receptors sense pathogen-associated molecular patterns (e.g., lipopolysaccharides) and trigger gene-expression changes that ultimately eradicate the invading microbes....
Toll-like receptors sense pathogen-associated molecular patterns (e.g., lipopolysaccharides) and trigger gene-expression changes that …
Toll-like receptor and RIG-I-like receptor signaling.
Kawai T, Akira S. Kawai T, et al. Ann N Y Acad Sci. 2008 Nov;1143:1-20. doi: 10.1196/annals.1443.020. Ann N Y Acad Sci. 2008. PMID: 19076341 Review.
Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) constitute distinct families of pattern-recognition receptors that sense nucleic acids derived from viruses and trigger antiviral innate immune responses. ...
Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) constitute distinct families of pattern-recognition receptors that …
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Lau J, Bloch P, Schäffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T. Lau J, et al. J Med Chem. 2015 Sep 24;58(18):7370-80. doi: 10.1021/acs.jmedchem.5b00726. Epub 2015 Sep 11. J Med Chem. 2015. PMID: 26308095
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as well as obesity. ...
Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-dail …
Lead- and drug-like compounds: the rule-of-five revolution.
Lipinski CA. Lipinski CA. Drug Discov Today Technol. 2004 Dec;1(4):337-41. doi: 10.1016/j.ddtec.2004.11.007. Drug Discov Today Technol. 2004. PMID: 24981612
Trends in the RO5 literature explosion that can be discerned are the further definitions of drug-like. This topic is explored in terms of drug-like physicochemical features, drug-like structural features, a comparison of drug-like and non-drug-like …
Trends in the RO5 literature explosion that can be discerned are the further definitions of drug-like. This topic is explored in term …
How Toll-like receptors influence Parkinson's disease in the microbiome-gut-brain axis.
Zhang Z, Liu Z, Lv A, Fan C. Zhang Z, et al. Front Immunol. 2023 May 3;14:1154626. doi: 10.3389/fimmu.2023.1154626. eCollection 2023. Front Immunol. 2023. PMID: 37207228 Free PMC article. Review.
Recently, a large number of experimenters have found that the pathogenesis of Parkinson's disease may be related to the gut microbiome and proposed the microbiome-gut-brain axis. Studies have shown that Toll-like receptors, especially Toll-like receptor 2 (TLR2) and …
Recently, a large number of experimenters have found that the pathogenesis of Parkinson's disease may be related to the gut microbiome and p …
C. elegans insulin-like peptides.
Zhu R, Chin-Sang ID. Zhu R, et al. Mol Cell Endocrinol. 2024 May 1;585:112173. doi: 10.1016/j.mce.2024.112173. Epub 2024 Feb 10. Mol Cell Endocrinol. 2024. PMID: 38346555 Free article. Review.
Invertebrates, such as C. elegans, have been instrumental in understanding the molecular mechanisms of insulin-like peptides. Here, we review the 40 insulin-like peptide genes encoded in the C. elegans genome. ...Thus C. elegans provides an excellent model to unders …
Invertebrates, such as C. elegans, have been instrumental in understanding the molecular mechanisms of insulin-like peptides. Here, w …
Editorial: Proglucagon-Derived Peptides.
Flatt PR, Knop FK, Tarasov AI. Flatt PR, et al. Front Endocrinol (Lausanne). 2021 Nov 11;12:776871. doi: 10.3389/fendo.2021.776871. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34858346 Free PMC article. No abstract available.
Toll-like receptors.
Moresco EM, LaVine D, Beutler B. Moresco EM, et al. Curr Biol. 2011 Jul 12;21(13):R488-93. doi: 10.1016/j.cub.2011.05.039. Curr Biol. 2011. PMID: 21741580 Free article. Review. No abstract available.
Have any strategies in Ph-like ALL been shown to be effective?
Aldoss I, Advani AS. Aldoss I, et al. Best Pract Res Clin Haematol. 2021 Mar;34(1):101242. doi: 10.1016/j.beha.2021.101242. Epub 2021 Jan 11. Best Pract Res Clin Haematol. 2021. PMID: 33762097 Review.
Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subset of B-cell ALL characterized by high rates of treatment failure. ...Notably, Ph-like ALL is not an uncommon entity in adults, and it's prevalence extends to older patients wit …
Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subset of B-cell ALL characterized by high rates …
Distribution of rare N4-like viruses in temperate estuaries unveiled by viromics.
Sun M, Chen F. Sun M, et al. Environ Microbiol. 2022 Dec;24(12):6100-6111. doi: 10.1111/1462-2920.16172. Epub 2022 Aug 29. Environ Microbiol. 2022. PMID: 36054739
When mapping reads to only known N4-like virus genomes, high occurrences of N4-like viruses infecting Roseobacter were found, with their diversity consisting mostly of locally isolated Roseobacter N4-like virus species. Both contig-based methods and Kaiju cla …
When mapping reads to only known N4-like virus genomes, high occurrences of N4-like viruses infecting Roseobacter were found, …
1,361,394 results
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